Clomicalm

Disclaimer: This site has been created by www.MedicAnimal.com for information purposes only. MedicAnimal is a proud retailer of Clomicalm but is not affiliated with or related to the manufacturer of Clomicalm and the contents of this site are neither sponsored or endorsed by the manufacturer of Clomicalm.

Buy Clomicalm

Introduction

Presentation

Clomicalm is available in divisible, flavoured tablets of 3 dosage strengths:
Clomicalm 5mg
Clomipramine hydrochloride
5.00mg
Clomicalm 20mg
Clomipramine hydrochloride
20.00mg
Clomicalm 80mg
Clomipramine hydrochloride
80.00mg

Uses

As an aid in the treatment of separation-related disorders in dogs manifested by destruction and inappropriate elimination (defecation and urination) and only in combination with behavioural modification techniques.

Dosage & administration

Dosage: Clomicalm is administered twice daily at a dose of 1-2mg/kg to give a total daily dose of 2-4mg/kg according to the following table:
 
Dosage per administration
Bodyweight
Clomicalm 5mg
Clomicalm 20mg
Clomicalm 80mg
1.25-2.5kg
>2.5-5kg
0.5 tablet
1 tablet
  
>5-10kg
>10-20kg
 
0.5 tablet
1 tablet
 
>20-40kg
>40-80kg
  
0.5 tablet
1 tablet
Administration: Clomicalm is given orally with or without food. In clinical trials, a treatment time of 2-3 months with Clomicalm in combination with behavioural modification techniques was sufficient to control the symptoms of separation-related disorders. Some cases may require longer treatment. In cases showing no improvement after 2 months, treatment with Clomicalm should be ceased.

Price comparison

Contra-indications, warnings, etc.

Contra-indications, warnings, etc
Contra-indications
Known hypersensitivity to clomipramine and related tricyclic antidepressants. Male breeding dogs.
Warnings
Clomicalm may cause sporadic vomiting, changes in appetite or lethargy. Vomiting may be reduced by co-administration with a small quantity of food.
Special precautions for use
Dog: It is recommended to administer Clomicalm to dogs with cardiovascular dysfunction or epilepsy with caution and only after an assessment of the benefit/risk ratio. Because of its potential anticholinergic properties, Clomicalm should also be used with care in dogs with narrow angle glaucoma, reduced gastrointestinal motility or urinary retention. Clomicalm should be used under veterinary supervision. The efficacy and safety of Clomicalm has not been established in dogs weighing less than 1.25kg or under 6 months of age.
Persons administering the product: In children, accidental ingestion should be regarded as serious. There is no specific antidote. In case of accidental ingestion, seek medical advice immediately and show the product label. Overdose in human beings causes anticholinergic effect although central nervous and cardiovascular systems may also be affected. People with known hypersensitivity to clomipramine should administer the product with caution.
Use during pregnancy and lactation: The safety of Clomicalm has not been established in female dogs during pregnancy and lactation. There was evidence of embryotoxic effects of clomipramine in laboratory animal studies.
Interaction with other medicaments: Recommendations on the interaction between Clomicalm and other medicaments are derived from studies in species other than dogs. Clomicalm may potentiate the effects of the anti-arrhythmic drug quinidine, anticholinergic agents (e.g. atropine), other CNS active drugs (e.g. barbiturates, benzodiazepines, general anaesthetics, neuroleptics), sympathomimetics (e.g. adrenaline) and coumarine derivatives. It is recommended not to administer Clomicalm in combination with, or within 2 weeks of therapy with, monoamine oxidase inhibitors. Simultaneous administration with cimetidine may lead to increased plasma levels of clomipramine. Plasma levels of certain anti-epileptic drugs, such as phenytoin and carbamazepine, may be increased by coadministration with Clomicalm.
Overdose: At overdose with 20mg/kg Clomicalm (5 times the maximum therapeutic dose), bradycardia and arrhythmias (atrioventricular node block and ventricular escape beats) were observed approximately 12 hours after dosing. Overdose with 40mg/kg (20 times the recommended dose) of Clomicalm produced hunched posture, tremors, flushed abdomen and decreased activity in dogs. Higher doses (500mg/kg i.e. 250 times the recommended dose) produced emesis, defecation, drooped eyes, trembling and quietness. Still higher doses (725mg/kg) produced, in addition, convulsions and death.
Environmental precautions: Any unused product or waste material should be disposed of in accordance with local requirements.

Pharmaceutical precautions

Store below 30°C in a dry place. Sensitive to moisture. Store unused product in the original container. For animal treatment only. Keep out of reach of children.

Packaging quantities

Each tablet size is supplied in plastic bottles containing 30 tablets (with desiccant).

Further information

Nil.

Disclaimer

This site has been created by www.MedicAnimal.com for information purposes only. MedicAnimal is a proud retailer of Clomicalm but is not affiliated with or related to the manufacturer of Clomicalm and the contents of this site are neither sponsored or endorsed by the manufacturer of Clomicalm.